Sex-Related Differences in the Mechanism of Functional Tricuspid Regurgitation

BackgroundPredictive factors of significant functional tricuspid regurgitation (FTR) are not completely understood. We investigated sex-related differences in predictors FTR progression.MethodClinical and echocardiographic variables were recorded a prospective single-centre observational cohort 251 consecutive stable patients with FTR. Multivariable logistic regression analyses stratified by sex performed to identify FTR.ResultsThe mean age the whole was 72.2±11.4 years, 133 (53%) women. Females tended have higher prevalence (22.6% vs 13.6%; p=0.066). Women also older than men (mean 74.4 69.6 years; p<0.001), more frequent history arterial hypertension, worse New York Heart Association class, E/e' quotient, left ventricular ejection fraction. The independent women atrial fibrillation (AF) (odds ratio [OR] 10.8, 95% confidence interval [CI] 2.9–40.7; indexed diameter annulus (OR 1.24, CI 1.04–1.47; p=0.017), pulmonary artery systolic pressure (PASP) 1.09, 1.04–1.15; p=0.001). outcome tenting height 2.71, 1.20–6.11; p=0.016), 1.98, 1.26–3.09; p=0.003), PASP 1.08, 1.01–1.16; p=0.021).ConclusionsThe presence AF longer convey greater risk females males, respectively. These findings suggest existence different physiopathological mechanisms involved progression both sexes. Predictive progression. Clinical p=0.021).